Paolo de Matteis was an Italian painter.

He was born in Piano Vetrale, a hamlet of Orria, in the current Province of Salerno, and died in Naples. He trained with Francesco di Maria in Naples, then with Luca Giordano. He served in the employ of the Spanish Viceroy of Naples. From 1702 to 1705, de' Matteis worked in Paris, Calabria, and Genoa. In Genoa, he painted an Immaculate Conception with St. Jerome Appearing to St. Sevrio. Returning to Naples, he painted decorative schemes for Neapolitan churches, including the vault of the chapel of San Ignatius in the church of Gesù Nuovo in Naples. He also painted an Assumption of the Virgin for the Abbey at Monte Cassino. Between 1723–1725, de' Matteis lived in Rome, where he received a commission from Pope Innocent XIII.

He had as pupils Ignacio de Oliveira, Bernardes Peresi, and members of the Sarnelli family including Francesco, Gennaro, Giovanni, and Antonio Sarnelli. Others who were his pupils were Giuseppe Mastroleo, Giovanni Pandozzi, and Nicolas de Filippis.