Marco Palmezzano was an Italian painter and architect, belonging to the Forlì painting school, who painted in a style recalling earlier Northern Renaissance models. He was mostly active near Forlì.

Palmezzano was born and died in Forlì, Romagna.

After his initial training with the painter Melozzo da Forlì — who had collaborated with Piero della Francesca and was widely esteemed as a master of perspective and foreshortening techniques— Palmezzano went to Rome in the early 1490s.

It is rumored that Palmezzano may have then traveled to Jerusalem to join the team painting frescoes at the Holy Cross church there, but no documentary evidence exists. He is, however, noted in property records as residing in Venice in 1495. Shortly thereafter, Palmezzano returned to Forlì, where he spent the rest of his long life—apparently with only brief excursions connected with commissions in other places in the region—until his death in 1539.

Among his pupils in Forlì, are listed Baldassarre Carrari il Giovane.