Francesco di Simone da Santacroce or Santa Croce was an Italian painter, active mainly in a Renaissance style. He was influenced by Giovanni Bellini.

He is best known for founding a studio that trained Francesco Rizzo, who inherited the studio after his master's demise, and later Palma il Vecchio and Andrea Previtali. His main pupil Francesco Rizzo is also sometimes known as Francesco da Santacroce.