Fabrizio Santafede or Fabrizio Santaféde was an Italian painter known for his altarpieces. He painted in a late-Mannerist style and his style marks the transition from Mannerism to Baroque.

Born in Naples, he began as a pupil of his father, the painter Francesco Santafede, and later became a pupil of Marco Pino. He may have been one of the collaborators of Pino on the decoration of the church of S Giovanni Fiorentini in Naples. He traveled extensively, including to Bologna, Florence, Rome, and Venice in his study of the great masters.

He became a dealer in antiques and paintings. He painted extensively in Naples, including an Assumption and Coronation of the Virgin for Santa Donna Regina Nuova. The Baroque painter Massimo Stanzione is mentioned as one of his pupils.

Legend has it that during the sack of Naples in 1647 by insurgents under Masaniello two houses in which Santafede had painted frescos were spared out of respect for the artist.