Guglielmo Da Re trained at the Accademia Olimpica, Vicenza, and at the Accademia di Brera, Milan. A series of his Venetian views and neo-settecento style genre scenes date to the early period of his activity. Subsequently, he emigrated to Buenos Aires where he focused on history subjects connected with Argentinian independence. He was also a portraitist, and on his return to Italy he specialised in painting on glass, creating the windows of Oleggio cathedral near Novara and the Tempio dei Caduti in Modena.