John Vanderlyn was a Dutch American neoclassicist painter.

Vanderlyn was born at Kingston, New York, and was the grandson of colonial portrait painter Pieter Vanderlyn. He was employed by a print-seller in New York, and was first instructed in art by Archibald Robinson (1765–1835), a Scotsman who was afterwards one of the directors of the American Academy of the Fine Arts. He went to Philadelphia, where he spent time in the studio of Gilbert Stuart and copied some of Stuart's portraits, including one of Aaron Burr, who placed him under Gilbert Stuart as a pupil.

He was a protégé of Aaron Burr who in 1796 sent Vanderlyn to Paris, where he studied for five years. He returned to the United States in 1801 and lived in the home of Burr, then the Vice President, where he painted the well-known portraits of Burr and his daughter. In 1802 he painted two views of Niagara Falls, which were engraved and published in London in 1804. He returned to Paris in 1803, also visiting England in 1805, where he painted the Death of Jane McCrea for Joel Barlow. Vanderlyn then went to Rome, where he painted his picture of Marius amid the Ruins of Carthage, which was shown in Paris, and obtained the Napoleon gold medal there. This success caused him to remain in Paris for seven years, during which time he prospered greatly. In 1812 he showed a nude Ariadne (engraved by Durand, and now in the Pennsylvania Academy), which increased his fame. When Aaron Burr fled to Paris, Vanderlyn was for a time his only support.

Vanderlyn returned to the United States in 1815, and painted portraits of various eminent men, including James Monroe, John C. Calhoun, Governor Joseph C. Yates, Governor George Clinton, James Madison, Robert R Livingston (New York Historical Society), Andrew Jackson, and Zachary Taylor. In 1834, he completed a posthumous full-length portrait of George Washington for the U.S. House of Representatives, based on Gilbert Stuart's 1796 Lansdowne portrait.

In 1825 Vanderlyn was one of the founders of the National Academy of Design, and taught at its school.