André-Jean Lebrun was a French sculptor.

André-Jean Lebrun was born in Paris in 1737. He studied under Jean-Baptiste Pigalle. Lebrun won the Grand Prix of the Académie royale de peinture et de sculpture in 1756. He tied with the sculptor Pierre-François Berruer (1733–1797), winning a scholarship to the Villa Medici in Rome. In Rome he made a number of statues for the church of San Carlo al Corso. These included a statue of Judith. He also carved a bust of Pope Clement XIII (1768). He became a member of the Académie de Saint-Luc and the Académie de Marseille.

Lebrun was invited to Poland at the recommendation of Madame Geoffrin. He was appointed chief sculptor to King Stanisław August Poniatowski. He also worked in Saint Petersburg, Russia, where he made a bust of the Empress Maria Feodorovna. In 1804, he became professor of sculpture at Vilnius University.

He died in Vilnius in 1811.