Anna Rosina de Gasc was a German portrait painter.

Anna Rosina was born into a family of painters of Polish noble origin in Berlin. Her mother was Maria Elizabeth Kahl from Pomerania. Her father, Georg Lisiewski (1674–1751), taught painting to Rosina and her siblings Anna Dorothea (1721–1782) and Christoph Friedrich (1725–1794). She later studied with the painter Antoine Pesne and learned his style of painting.

In 1757, Rosina was appointed as court painter by Frederick Augustus of Anhalt-Zerbst. During her ten-year stay at the court, she painted a gallery of forty ladies. Later, she moved to the ducal court in Brunswick, where she received a generous grant from Duchess Philippine Charlotte of Brunswick-Wolfenbüttel.

Her work is held in the permanent collections of several museums worldwide, including the Kunsthistorisches Museum, the University of Michigan Museum of Art, and the National Museum, Warsaw.

In 1741, Anna Rosina married the Prussian court painter David Matthieu (1697–1756) and became the stepmother of Georg David Matthieu. After David's death, she married in 1760 to Louis de Gasc, who was a friend of Gotthold Ephraim Lessing. She had two children with him.

Anna Rosina de Gasc died in 1783 in Dresden.