Anthonie Palamedes, also Anthonie or Antonie Palamedesz., was a Dutch Golden Age portrait painter.

According to Houbraken his father was a Flemish sculptor who carved semi-precious stone such as Jasper, Porphyry, and Agate into vases and other decorative art. His father had traveled to England in service of King James of Scotland, but after Anthonie's older brother Palamedes was born, the family returned to Delft where the boys grew up. Anthonie survived his brother Palamedes who died young in 1638. He entered the Delft Guild of St. Luke in 1636 and was in 1673 hoofdman or deacon of that guild for the last time.

Palamedes primarily painted portraits and genre works, while his brother Palamedes Palamedesz. I was a battle scene painter. According to the RKD, Anthonie was the oldest brother, taught by Michiel Jansz. van Mierevelt and Hans Jordaens and had joined the Delft Guild of Saint Luke already in 1621. He was married twice, and had four children in total. His pupils were his younger brother Palamedes, his own son Palamedes II, and the painter Ludolf de Jongh. Anthonie died in Amsterdam in 1673.