David Bryce FRSE FRIBA RSA was a Scottish architect.

Bryce was born at 5 South College Street in Edinburgh, the son of David Bryce (1763–1816) a grocer with a successful side interest in building. He was educated at the Royal High School and joined the office of the architect William Burn in 1825, at the age of 22. By 1841, Bryce had risen to be Burn's partner. Burn and Bryce formally dissolved their partnership in 1845, with disputes over the building of St Mary's Church, Dalkeith, Midlothian, for the Duke of Buccleuch.

Burn moved to London, and Bryce succeeded to a very large and increasing practice, to which he devoted himself with the enthusiasm of an artistic temperament and untiring energy and perseverance. In the course of a busy and successful career, which was actively continued almost down to his death, he attained the foremost place in his profession in Scotland, and designed important works in most of the principal towns of the country.

In the 1830s Bryce was living at 8 Great Stuart Street on the Moray Estate in Edinburgh's West End.

In 1835 he was elected an associate of the Royal Scottish Academy, and in the following year became an academician. He was also a fellow of the Royal Institute of British Architects, of the Architectural Institute of Scotland, of the Royal Society of Edinburgh, and officiated for several years as grand architect to the Grand Lodge of Masons in Scotland. He died on 7 May 1876, after a short illness from bronchitis, leaving many important works in progress, which were completed under the superintendence of his nephew, who had been his partner for some years, and who succeeded to his business. He died unmarried, but had one son with his common law wife, Janet Tod (1797-1884), David Bryce Tod, whom he recognised in later life, and in his will.

He is buried in the New Calton Cemetery in Edinburgh just west of the main north-south path, beside his nephew, John Bryce, also an architect, who worked with him in later life.