Frank Henderson was a Native American artist.
His Indian name is unknown, but he was called Frank Henderson in 1879 when he was sent at age 17 from Darlington, Indian Territory (now western Oklahoma) to the Carlisle Indian School in Carlisle, Pennsylvania. Orphaned as a child, he suffered homesickness and poor health during the year and a half he was at Carlisle. Returning to Darlington in 1881, he worked with missionaries and finished his book of drawings before his death at age 23 in 1885.