Pieter Neefs the Elder or Pieter Neeffs the Elder was a Flemish painter who specialized in architectural interiors of churches. Active in Antwerp, he was influenced by the works of the Dutch architectural painters Hendrik van Steenwijk the Elder and the Younger. His principal contribution to the genre were his nocturnal church interiors lit by two light sources.

The year of birth of Pieter Neefs is not known with certainty. It is placed some time between 1578 and 1590. He is believed to have been born in Antwerp. His father was Aart Neefs, a cloth merchant and innkeeper who had difficulty making ends meet after losing most of his fortune during the Spanish Fury. Pieter's mother was Margaretha Verspreet.

The name of the teacher of Pieter Neefs has not been preserved, In 1610 Pieter became a free master of the Antwerp Guild of St Luke. He established himself as a specialist of church interiors, a genre that had been relatively little practiced in Flanders before him. He became so successful with his architectural paintings that he was able to get leading Antwerp painters to paint the staffage in his works.

Pieter Neefs married Maria Louterbeens on 30 April 1612. The couple had five children of whom the second and third-born Lodewijk and Pieter became painters. Their works were very close to their father's, and attributions of their individual hands can be difficult.

Despite his success Pieter Neefs appears to have suffered financial difficulties. His only pupil was Laureis de Cater, who turned out to have insufficient talent to become admitted as a master to the Guild.

The artist died some time between February 1656, when he is recorded dealing with an inheritance, and 1661, when he is recorded as deceased by the biographer Cornelis de Bie in the volume of his Het Gulden Cabinet, which appeared in 1661.