John Samuel Pughe, was a Welsh-born American political cartoonist, best known for his illustrations for Puck magazine.

John Samuel Pughe was born in Dolgelley, Merionethshire, Wales, and brought to America by his parents when he was two years old. He studied art at Cooper Union.

J. S. Pughe illustrated news stories for the New York Recorder, Brooklyn Life, and the Brooklyn edition of the World as a young man. He began working at Puck magazine in 1894. He was a regular contributor there until his last cartoon for them, in December 1908.

Pughe died in 1909, age 38, at Lakehurst, New Jersey, where he had been spending several months to improve his health.