George Louis Palmella Busson du Maurier was a Franco-British cartoonist and writer known for his work in Punch and for his Gothic novel Trilby, which featured the character Svengali. He was the father of the actor Sir Gerald du Maurier and grandfather of the writers Angela du Maurier and Dame Daphne du Maurier and artist Jeanne du Maurier. He was also the father of Sylvia Llewelyn Davies and grandfather of the five boys who inspired J. M. Barrie's Peter Pan.

George du Maurier was born in Paris, the son of Louis-Mathurin Busson du Maurier and Ellen Clarke, daughter of the Regency courtesan Mary Anne Clarke. He was brought up to believe his aristocratic grandparents had fled from France during the Revolution, leaving vast estates behind, to live in England as émigrés. In fact, du Maurier's grandfather, Robert-Mathurin Busson, was a tradesman who left Paris in 1789 to avoid charges of fraud and later changed the family name to the grander-sounding du Maurier.

Du Maurier studied art in Paris in the studio of Charles Gleyre, and moved to Antwerp, Belgium, where he lost the vision in his left eye. He consulted an oculist in Düsseldorf, Germany. He was reportedly studying chemistry at University College, London, in 1851. He is recorded in the 1861 England Census as a lodger at 85 Newman St in Marylebone. He met Emma Wightwick in 1853 and married her a decade later, on 3 January 1863, at St Marylebone, Westminster. Moving frequently over the course of their marriage, the couple first settled in Hampstead in 1869, initially at Gang Moor near the Whitestone Pond for three years, before moving to 27 Church Row and later at New Grove House in 1881. In 1891, the family is recorded as residing at 2 Porchester Rd in Paddington. They had five children: Beatrix (known as Trixy), Guy, Sylvia, Marie Louise (known as May) and Gerald.

Du Maurier became a member of staff at the British satirical magazine Punch in 1865, drawing two cartoons a week. His commonest targets were the affected manners of Victorian society, the bourgeoisie and members of Britain's growing middle class in particular. His most enduring cartoon, True Humility (1895), popularised the expressions "good in parts" and "a curate's egg". In it, a bishop addresses a humble curate, whom he has invited to breakfast: "I'm afraid you've got a bad egg, Mr. Jones." The curate replies, "Oh no, my Lord, I assure you – parts of it are excellent!" The gag was not original to du Maurier, however, as it had appeared in a similar cartoon a few months earlier in Judy, a less widely read competitor to Punch. In an earlier (1884) cartoon, du Maurier coined the expression "bedside manner", with which he satirised medical care. Another of his notable cartoons depicted a fanciful videophone conversation in 1879, using a device he called "Edison's telephonoscope."

While producing black-and-white drawings for Punch, du Maurier created illustrations for several other popular periodicals: Harper's, The Graphic, The Illustrated Times, The Cornhill Magazine, and the religious periodical Good Words. Furthermore, he did illustrations for the serialisation of Charles Warren Adams's The Notting Hill Mystery, which is often seen as the first detective story of novel length to have appeared in English. Among several other novels he illustrated was Misunderstood by Florence Montgomery in 1873.

His deteriorating eyesight caused du Maurier to reduce his involvement with Punch in 1891 and settle in Hampstead, where he wrote three novels. His first, Peter Ibbetson (1891), was a modest success at the time and later adapted for stage and screen, most notably in a 1935 film, and as an opera.

His second novel, Trilby, published in 1894, fitted into the gothic horror genre that was undergoing a revival. Hugely popular, it tells of a poor artist's model, Trilby O'Ferrall, transformed into a diva under the spell of an evil musical genius, Svengali. Soap, songs, dances, toothpaste, and even the city of Trilby, Florida, were named after her, as was the variety of soft felt hat with an indented crown worn in the London stage dramatisation of the novel. The plot inspired Gaston Leroux's 1910 novel Phantom of the Opera and innumerable works derived from it. Du Maurier eventually came to dislike the persistent attention the novel was given.

The third novel was a long, largely autobiographical work entitled The Martian, published posthumously in 1898.

Du Maurier died on 8 October 1898 and was buried in St John-at-Hampstead churchyard in Hampstead. The success of his writings and illustrations allowed du Maurier to leave a then staggering amount of £47,555 in his will.

Du Maurier was a close friend of Henry James, the novelist; their relationship was fictionalised in David Lodge's Author, Author (2004).