Jean-Guillaume Moitte was a French sculptor.
Moitte was the son of Pierre-Etienne Moitte. He became the sculptor of Pigalle then Jean-Baptiste Lemoyne. He won the Prix de Rome for sculpture in 1768 with David carrying the head of Goliath in triumph. He then entered the École royale des élèves protégés before a stay at the Rome, though it was cut short due to illness.

He worked for the king's goldsmith Auguste and participated in decorative works for monuments in capital. He was commissioned to produce sculptures of generals who had died in battle such as one of Custine for the musée de Versailles, the tomb of Desaix at Grand Saint-Bernard or that of Leclerc at the Panthéon de Paris. He also designed and sculpted the pediment for the Panthéon during the French Revolution, with the theme of the Fatherland crowning the civil and heroic virtues Moitte and Philippe-Laurent Roland were the main sculptors for the exterior of the hôtel de Salm.

He was a member of the Institut de France, the Légion d'honneur and professor of the École des Beaux-Arts de Paris.