Carlo Francesco Nuvolone was an Italian painter of religious subjects and portraits who was active mainly in Lombardy. He became the leading painter in Lombardy in the mid-17th century, producing works on canvas as well as frescoes. Because his style was perceived as close to that of Guido Reni he was nicknamed il Guido della Lombardia (the Guido of Lombardy).

Carlo Francesco Nuvolone was born in Milan. His father Panfilo Nuvolone was a painter of frescoes and altarpieces, in a style still linked to late Mannerism, and of still lifes. Carlo Francesco had a brother called Giuseppe who also became a painter.

After working with his father, Carlo Francesco studied at the Accademia Ambrosiana in Milan under Giovanni Battista Crespi (il Cerano). In that studio he would have encountered Daniele Crespi and Giulio Cesare Procaccini.

He later worked in Milan and its environs. During the 1650s, Nuvolone painted frescoes for the Cappella di San Michele in the Certosa di Pavia and contributed to the decorations of the sacro monte (hillside shrine) at Varese, an important local pilgrimage site. He later also painted frescos at the Sacro Monte di Orta. His brother occasionally assisted him with his fresco work.

Among his pupils were Giuseppe Zanata, Federigo Panza, Filippo Abbiati, and Pietro Maggi.