Giovanni Andrea Sirani was an Italian Baroque painter from Bologna.

He is best known as the father of the female painter Elisabetta Sirani. Sirani trained initially with Giacomo Cavedone, then worked in the studio with Guido Reni. He became entangled in various conspiracies circling around the death of his daughter in 1665. While Giovanni accused a maid of poisoning his daughter, others saw Giovanni as the origin of death from stomach ulcer by overwork.