Domenico Antonio Vaccaro was an Italian painter, sculptor and architect. He created many important sculptural and architectural projects in Naples. His later works are executed in an individualistic Rococo style.

Domenico Antonio Vaccaro was born in Naples as the son of Lorenzo Vaccaro. His father Lorenzo was a pupil of Cosimo Fanzago. Domenico Antonio Vaccaro first studied under his father. He subsequently trained in the workshop of Francesco Solimena.

He initially dedicated himself to painting but from around 1707 he appears to have practised almost exclusively as a sculptor and architect. In the 1730s he resumed painting.

Works of interest include a statue of Moses in the church of San Ferdinando, interior work at the Chiesa di Santa Maria in Portico, and the statues of Penitence and Solitude on the premises of the monastery (now museum) of San Martino.

He also designed the Palazzo Tarsia and Palazzo Caravita at Portici, the church of San Giovanni at Capua, and he reconstructed the Cathedral of Bari. He helped reconstruct the church of Santa Maria della Pace, damaged after an earthquake. He designed the Palace of the Immacolatella at the water's edge in central Naples. He designed the small church of Santa Maria della Concezione a Montecalvario, Naples.